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Observation on the Curative Effect of Trimebutine Maleate Capsule Combined with Polyethylene Glycol 4000 Powder in Treating Constipation Irritable Bowel Syndrome

Time:2017/7/17 17:17:30

OBJECTIVE: To observe the efficacy and safety of trimebutine maleate capsule combined with polyethylene glycol 4000 powder in the treatment of constipation-type irritable bowel syndrome.

Methods: 104 patients with constipation-type irritable bowel syndrome who were eligible for Rome Ⅲ were randomly divided into two groups. Treatment group 54 cases: trimebutine maleate capsules 0.2g / times, 3 times / d, combined with polyethylene glycol 4000 scattered 10g / times, add water 300 ~ 400mL taken, 2 times / d; control group of 50 cases: trimebutine maleate 0.2g / times, 3 times / d, treatment were 4 weeks.

Results: Compared with the control group, the total effective rate of abdominal symptoms(abdominal pain, abdominal distension) was 96% and 90%, respectively. 2 groups were significantly improved, the treatment group abdominal symptoms and constipation improvement than the control group is more obvious, the difference was statistically significant (P <0.05). There was no significant difference in adverse reactions between the two groups.

Conclusion: Trimebutine maleate capsule combined with polyethylene glycol 4000 powder is effective and safe in the treatment of constipation type irritable bowel syndrome. It is worthy of clinical application.