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Yourlocation:Home >News> Effects of trimebutine maleate (TM-906) on the spontaneous contraction of isolated guinea pig colon were investigated

Effects of trimebutine maleate (TM-906) on the spontaneous contraction of isolated guinea pig colon were investigated

Time:2015/9/30 7:18:54

TM-906 in the concentrations of 10-6 g/ml and 10-5 g/ml increased the tone without affecting the amplitude of the spontaneous contraction in the preparations with low tone, whereas it decreased the tone and the amplitude of the spontaneous contraction in the preparations with high tone. 

trimebutine maleate

At the higher concentration (10-4 g/ml), TM-906 decreased the tone and finally abolished the spontaneous contraction in any preparation. 


The increase in tone induced by trimebutine maleate (TM-906) was prevented by diltiazem and exposure to Ca++-free solution, but not by tetrodotoxin, atropine, phentolamine or propranolol, and depended on the extracellular concentration of CaCl2. 

trimebutine maleate

On the other hand, the decrease in tone and amplitude of the spontaneous contraction produced by trimebutine maleate (TM-906) were not prevented by tetrodotoxin, phentolamine or propranolol. 


trimebutine maleate (TM-906) further increased the tone increased by 10 mM KCI, while it decreased the tone increased by 30 mM KCI. From results described above, it is suggested that trimebutine maleate (TM-906) possesses both a relaxing effect and an excitatory effect which seem to be due to its direct action on the smooth muscle.


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