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The Analgesic Mechanism of Trimebutine Maleate

Time:2015/7/28 7:05:10

The analgesic effect of trimebutine maleate (TM) and its mechanism were studied in this paper.It was found that the writhing response induced by acetic acid was inhibited by TM (40、80 μg/mouse,icv).TM induced analgesia was significantly reduced by reserpine and naloxone,and its analgesic effect was reduced and inhanced by CaCl\-2 and EDTA respectively.It was concluded that the analgesic effect of TM was of partical central action and might be related to the opioid receptor,the central monoamine transmitters and the inhibition of calcium influx.


Efficacy of Trimebutine Maleate in the Treatment of Functional Dyspepsia in Childhood


Peripheral μ-, k- and δ-opioid agonist trimebutine maleate is considered to be an effective therapeutic drug for the treatment of functional gastrointestinal disorders. Ninety-two paediatric outpatients (12- 17 year-old) suffering from functional dyspepsia (epigastric pain and meal-induced dyspeptic symptoms) were enrolled in a prospective openlabel study. For ethical reasons, no placebo group was included. Patients were treated with trimebutine maleate (200 mg three times daily). After a 3-week treatment there was a significant decrease in scores of epigastric pain (p<0.05), postprandial fullness (p<0.05), early satiety (p<0.05), nausea (p<0.05) and belching (p<0.05). The treatment regimen was well tolerated and demonstrated a good compliance. In conclusion, we postulate that trimebutine maleate is an effective medication for relief of main symptoms associated with functional dyspepsia syndrome in childhood. Because of the limited data on therapeutic interventions in functional dyspepsia in childhood and increasing demand for therapies to treat this disorder, further evaluation of the efficacy of trimebutine treatment for children is certain.