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Trimebutine maleate in attacks of abdominal pain in ibs. an attack of abdominal

Time:2015/9/16 2:16:58

pain is a frequent reason for referral of an IBS patient. In this situation, spasmolytic drugs may exert an analgesic effect, but do not influence the motility changes observed in these patients." They are also effective in relieving pain from other organs (e.g. urinary tract,female genital tract) and this may lead to misinterpretation of a favourable clinical outcome.

Optimal treatment of the acute symptoms of IBS requires drugs that act specifically on the gastrointestinal tract and are rapidly effective. A few studies have evaluated the

effect of Trimebutine maleate in short-term treatment(3 - 15 days).

Luttecke'" showed that Trimebutine maleate, 200mg, orally three times daily for 3 days, was more effective than placebo in relieving abdominal pain in 39 IBS patients.

Abdominal pain was significantly decreased in 27 patients after Trimebutine maleate, but in only two after placebo (P < 0.001). In another study evaluating a 3-day treatment, Trimebutine maleate,

200 mg, orally, three times daily, was more effective than placebo in relieving acute pain,but no difference was observed between Trimebutine maleate, 100 mg, three times daily, and

placebo." A study comparing the effects of Trimebutine maleate, 500 mg, with mebeverine, 450mg, in a cross-over design (2 X 1 week) is presented in the same report: both treatments

were equally effective in terms of pain relief."