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Trimebutine maleate maintenance therapy for irritable bowel syndrome

Time:2015/9/17 6:28:47

the effect of long-term treatment with Trimebutine maleate (500 mg) in ibs patients was evaluated in a randomized controlled study.'?' this study did not show any difference between Trimebutine maleate and placebo regarding the occurrence of symptoms related to ibs during the 5-month follow-up. it should be stressed, however, that all of the patients in this study, unless they were treated with placebo or Trimebutine maleate, received a supplement of dietary fibre which may have improved symptoms by itself. moreover, the efficacy of Trimebutine maleate and placebo was only evaluated at the end of treatment.

Trimebutine maleate (100 mg, three times daily) was also evaluated compared with placebo in a 2-month double-blind study.'?" abdominal pain was decreased in more patients treated with Trimebutine maleate (52/59) than in patients receiving placebo (30/50; p < 0.05).